adipose tissue inflammation and ectopic lipid accumulation definition

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Adipose tissue inflammation and ectopic lipid accumulation ...- adipose tissue inflammation and ectopic lipid accumulation definition ,Molecular mechanism of obesity-induced adipose tissue inflammation; the role of Mincle in adipose tissue fibrosis and ectopic lipid accumulation.A review on the biology and properties of adipose tissue ...Jul 09, 2020·Obesity exhibits a correlation with metabolic inflammation and endoplasmic reticulum stress, promoting the progression of metabolic disease such as diabetes, hyperlipidemia, hyperuricemia and so on. Adipose tissue macrophages (ATMs) are central players in obesity-associated inflammation and metabolic diseases. Macrophages are involved in lipid and energy metabolism and mitochondrial …



Macrophage accumulation and fibrosis in adipose tissue is ...

Introduction. Obesity is marked by excess storage of lipids and a chronic pro-inflammatory state in adipocytes ().The obesity-associated low-grade inflammation is sustained by the increase of macrophages in adipose tissue and is strongly associated with increased ectopic fat accumulation in the liver (), which can lead to non-alcoholic fatty liver disease (NAFLD), a process that begins early ...

Obesity, Adipose Tissue, Inflammation and Update on ...

Nov 12, 2014·Adipose tissue is considered a dynamic organ with extremely sophisticated functions. Obesity is associated with low chronic inflammation through the secretion of adipokines. Inflammation mediates on the development of metabolic diseases associated with obesity, dyslipidaemia, hypertension and type 2 diabetes.

Adipose-derived autotaxin regulates inflammation and ...

Feb 07, 2019·Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). We generated mice with global inducible post-natal inactivation or adipose-specific loss of the Enpp2 gene encoding ATX. The animals are phenotypically unremarkable and exhibit differences in adipocyte size and adipose tissue expression of inflammatory genes after high fat feeding without …

Frontiers | Adipose Tissue Distribution, Inflammation and ...

Feb 25, 2020·Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body. The cellular composition, secretome, and location of these adipose depots define their function in health and metabolic disease.

Adipose Tissue in Health and Disease | IntechOpen

Jan 09, 2020·Obesity, being an epidemy these days, is the trigger of metabolic disturbances such as cardiovascular disease, type 2 diabetes, and insulin resistance. Defined as an increase in fat storage, adipose tissue has been put under the spotlight as the culprit of these conditions, as it is composed not only by adipocytes but of any immune system cell and a singular extracellular matrix.

JCI - Adipose tissue remodeling and obesity

Jun 01, 2011·In this state, they fuse to phagocytose the residual lipid droplet, forming large lipid-laden multinucleated syncytia in the process, a commonly accepted hallmark of chronic inflammation (10, 14). Using a transgenic model of inducible lipoatrophy, we have previously demonstrated that massive adipocyte death can indeed drive rapid accumulation ...

JCI - Contribution of adipogenesis to healthy adipose ...

Oct 01, 2019·This is associated with ectopic lipid accumulation and insulin resistance, similar to what is observed in the lipodystrophy. Right: Metabolically healthy obesity is characterized by adequate expansion of protective subcutaneous depots, healthy adipose tissue remodeling (adipocyte hyperplasia), and limited ectopic lipid deposition.

Adipose Tissue: Not Just Fat - The Medical Biochemistry Page

Specific metabolic processes regulated by adipose tissue include lipid metabolism, glucose homeostasis, inflammation, angiogenesis, hemostasis (regulation of blood coagulation), and blood pressure. The major form of adipose tissue in mammals (commonly referred to as “fat”) is white adipose tissue…

Macrophage-inducible C-type lectin underlies obesity ...

Sep 19, 2014·In obesity, a paracrine loop between adipocytes and macrophages augments chronic inflammation of adipose tissue, thereby inducing systemic insulin resistance and ectopic lipid accumulation. Obese ...

Frontline Science: Rapid adipose tissue expansion triggers ...

Mar 01, 2018·The appearance of lipid-laden CD11c + ATMs at peak adipocyte size supports a role in responding to ectopic lipid accumulation within adipose tissue. In contrast, ATDCs increase independently of proliferation and may be derived from circulating precursors.

Adipose tissue and insulin resistance in obese - ScienceDirect

May 01, 2021·The impaired fat storage capacity of the adipose tissue results in ectopic fat deposition and contributes to ... Hepatic lipid accumulation in the liver is counteracted by increased lipid ... Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance. Nutrients, 5 (9 ...

Ectopic Fat and Insulin Resistance: Pathophysiology and ...

The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function.

Ectopic fat | definition of ectopic fat by Medical dictionary

ectopic fat: Fat that collects in abnormal locations in the body and adversely affects health. These locations include: the liver (steatohepatitis), muscle (marbling), and around the intraperitoneal organs (visceral fat). See also: fat

Adipose tissue inflammation and ectopic lipid accumulation ...

Adipose tissue inflammation and ectopic lipid accumulation [Review] Takayoshi Suganami , Miyako Tanaka , Yoshihiro Ogawa. Author information. Takayoshi …

IJMS | Free Full-Text | Epicardial Adipose Tissue ...

The development of MetS is inherently linked to the metabolic activity of adipose tissue; namely via adipose tissue inflammation, aberrant accumulation of ectopic lipid deposits, and mitochondrial dysfunction, particularly in skeletal muscle and liver . MetS is proposed to be a systemic manifestation of adipose tissue disease . Adipose tissue ...

Contribution of adipogenesis to healthy adipose tissue ...

Oct 01, 2019·Inadequate energy storage in adipose tissue underlies insulin resistance. Left: Lipodystrophy is characterized by an absolute or partial adipocyte deficiency, triggered by impaired adipocyte differentiation or triglyceride synthesis. This leads to ectopic lipid accumulation in other tissues, including the liver, skeletal muscle, heart, and ...

Adipose tissue in health and disease | Open Biology

Dec 09, 2020·Indeed, ectopic lipid accumulation in cardiac and skeletal muscle can result in tissue-specific and systemic insulin resistance [113–117]. As a whole, these findings underscore the importance of proper lipid storage within the AT and away from internal organs or skeletal muscles.

Adipose tissue and metabolic syndrome: too much, too ...

Aug 20, 2015·For instance, lower body adipose tissue may be protective whereas upper body adipose tissue may promote the syndrome. One view holds that in either case, the accumulation of ectopic fat in muscle and liver is the driving factor underlying the syndrome. If so, there may be some link between adipose tissue fat and ectopic fat.

Inflammatory stress exacerbates ectopic lipid deposition ...

Jun 30, 2011·Chronic systemic inflammation and abnormal free fatty acid metabolism are closely related to ectopic lipid deposition. In this study, we investigate if inflammation tissue-specifically disrupts lipogenesis and lipolysis in nonadipose tissues and adipose tissue, resulting in ectopic lipid deposition in C57BL/6J mice. We used casein injection in C57BL/6J mice to induce a chronic systemic ...

Adipose Tissue Dysfunction as Determinant of Obesity ...

Excessive ectopic lipid accumulation leads to local inflammation and insulin resistance (IR). Indeed, overnutrition triggers uncontrolled inflammatory responses …

Adipose tissue, diet and aging | Request PDF

In diet-induced obesity, increased lipid burden in adipose tissue and ectopic lipid accumulation in non-adipose tissues causes multiple dysfunction of the organs (8).

Adipose-derived autotaxin regulates inflammation and ...

Feb 07, 2019·Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). We generated mice with global inducible post-natal inactivation or adipose-specific loss of the Enpp2 gene encoding ATX. The animals are phenotypically unremarkable and exhibit differences in adipocyte size and adipose tissue expression of inflammatory genes after high fat feeding without …

Adipose tissue metabolism and inflammation in obesity ...

Jan 01, 2019·Adipose Tissue Lipid Metabolism. To accommodate the need for additional fat storage under conditions of energy excess, adipose tissue enlarges. Adipose …

Contribution of adipogenesis to healthy adipose tissue ...

Oct 01, 2019·Inadequate energy storage in adipose tissue underlies insulin resistance. Left: Lipodystrophy is characterized by an absolute or partial adipocyte deficiency, triggered by impaired adipocyte differentiation or triglyceride synthesis. This leads to ectopic lipid accumulation in other tissues, including the liver, skeletal muscle, heart, and ...

Adipose tissue inflammation and ectopic lipid accumulation ...

Adipose tissue inflammation and ectopic lipid accumulation. Takayoshi Suganami, Miyako Tanaka, Yoshihiro Ogawa. ... Recent evidence suggests that reduced …

Adipose tissue expandability, lipotoxicity and the ...

Mar 01, 2010·Ectopic lipid accumulation in non-adipocyte cells causes lipotoxic insults including insulin resistance, apoptosis and inflammation. This article discusses the links between adipokines, inflammation, adipose tissue expandability and lipotoxicity.