cell and tissue engineering in lymph nodes for cancer immunotherapy research

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Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes ...- cell and tissue engineering in lymph nodes for cancer immunotherapy research ,The migration status of T cells within the densely packed tissue environment of lymph nodes reflects the ongoing activation state of adaptive immune responses. Upon encountering antigen-presenting dendritic cells, actively migrating T cells that are specific to cognate antigens slow down and are eventually arrested on dendritic cells to form immunological synapses.Physiologically triggered injectable red blood cell-based ...Hydrogels are widely used for drug delivery and tissue engineering. Here we developed a simple injectable red blood cells (RBCs)-based gel for cancer photo-immunotherapy. We find that subcutaneous injected homologous RBCs could form hydrogel-like composition in mice, due to the infiltrated platelets and thrombin under physiological environment.



Kam W. Leong | Biomedical Engineering

He uses polymeric biomaterials to deliver chemotherapeutics, DNA-based therapeutics, and cells for cancer therapy, gene therapy, immunotherapy, and cell therapy. He also uses tissue engineering principles and stem cell engineering to construct human tissue-on-a-chip for disease modeling and …

(PDF) Targeting dendritic cells with nano-particulate PLGA ...

C.G. Figdor, Effective migration of antigen-pulsed dendritic cells to lymph nodes [89] P. Elamanchili, M. Diwan, M. Cao, J. Samuel, Characterization of poly(D,L-lactic- in melanoma patients is determined by their maturation state, Cancer Res. 63 co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens (2003) 12.

Decellularized Lymph Nodes as Scaffolds for Tissue ...

Sep 01, 2015·Background: The lymphatic system is commonly injured during cancer treatment. However, despite the morbidity of these injuries, there are currently no options for replacing damaged lymphatics. The purpose of this study was to optimize methods for decellularization of murine lymph nodes (LN) and to determine if these scaffolds can be used to tissue engineer lymph node-like …

Engineering New Approaches to Cancer Vaccines | Cancer ...

Aug 01, 2015·Motivation for Cancer Vaccine Engineering. Therapeutic vaccination is one of the oldest and most studied concepts in cancer immunotherapy. Yet, in contrast with prophylactic vaccines against infectious disease, which have had a major impact on public health, therapeutic vaccines against cancer have generally been much less successful, and only a single cancer vaccine has been FDA …

(PDF) Targeting dendritic cells with nano-particulate PLGA ...

C.G. Figdor, Effective migration of antigen-pulsed dendritic cells to lymph nodes [89] P. Elamanchili, M. Diwan, M. Cao, J. Samuel, Characterization of poly(D,L-lactic- in melanoma patients is determined by their maturation state, Cancer Res. 63 co-glycolic acid) based nanoparticulate system for …

[PDF] The intercell dynamics of T cells and dendritic ...

T cells play a central role in immunity towards cancer and infectious diseases. T cell responses are initiated in the T cell zone of the lymph node (LN), where resident antigen-bearing dendritic cells (DCs) prime and activate antigen-specific T cells passing by. In the present study, we investigated the T cell : DC interaction in a microfluidic device to understand the intercellular dynamics ...

Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes ...

The migration status of T cells within the densely packed tissue environment of lymph nodes reflects the ongoing activation state of adaptive immune responses. Upon encountering antigen-presenting dendritic cells, actively migrating T cells that are specific to cognate antigens slow down and are eventually arrested on dendritic cells to form immunological synapses.

Application of tissue engineering to the immune system ...

Nov 16, 2012·The goal of tissue engineering and regenerative medicine is to develop synthetic versions of human organs for transplantation, in vitro toxicology testing and to understand basic mechanisms of organ function. A variety of different approaches have been utilized to replicate the microenvironments found in lymph nodes including the use of a variety of different bio-materials, …

Polymeric scaffolds for antitumor immune cell priming ...

1.Introduction. Cancer is a life-threatening disorder, and is the second-leading cause of death worldwide, with an estimated 606,520 deaths projected in the USA alone for 2020 .Traditional treatments such as radiation, chemotherapy, and targeted cancer therapies have been associated with limited efficacy, leading to drug resistance, toxicity, and minimal survival benefit , , .

Motility Dynamics of T Cells in Tumor-Draining Lymph Nodes ...

The migration status of T cells within the densely packed tissue environment of lymph nodes reflects the ongoing activation state of adaptive immune responses. Upon encountering antigen-presenting dendritic cells, actively migrating T cells that are specific to cognate antigens slow down and are eventually arrested on dendritic cells to form immunological synapses.

Immune-engineered device targets chemo-resistant lymphoma ...

Apr 10, 2018·Non-Hodgkin lymphoma, a cancer that is diagnosed in the U.S. more than 70,000 times annually, arises from overly proliferating immune cells within the body’s lymph nodes, which are connected to a network of lymph vessels through which lymphatic fluid flows. The most common type of lymphoma is diffuse large B-cell …

Cell and tissue engineering in lymph nodes for cancer ...

Jan 01, 2020·In cancer, lymph nodes (LNs) coordinate tumor antigen presentation necessary for effective antitumor immunity, both at the levels of local cellular interactions and …

Immunotherapy for Hodgkin Lymphoma | Hodgkin Antibody ...

Immunotherapy is the use of medicines to help someone’s immune system better recognize and destroy cancer cells. Immunotherapy can be used to treat some people with Hodgkin lymphoma (HL). Monoclonal antibodies. Antibodies are proteins made by your immune system to help fight infections.

Polymeric scaffolds for antitumor immune cell priming ...

1.Introduction. Cancer is a life-threatening disorder, and is the second-leading cause of death worldwide, with an estimated 606,520 deaths projected in the USA alone for 2020 .Traditional treatments such as radiation, chemotherapy, and targeted cancer therapies have been associated with limited efficacy, leading to drug resistance, toxicity, and minimal survival benefit , , .

Cancer Immunotherapy – LAMP Biomaterials

However, the fight against cancer remains a challenge because cancer cells are able to hide from the immune system. Over 21,7 million of new cancer cases are expected to be diagnosed in 2030, and it is predicted that over 13 million people will die of cancer this year. Thus, one of the strategies to reverse the situation is immunotherapy.

Cell and tissue engineering in lymph nodes for cancer ...

In cancer, lymph nodes (LNs) coordinate tumor antigen presentation necessary for effective antitumor immunity, both at the levels of local cellular interactions …

Delivery strategies of cancer immunotherapy: recent ...

Nov 28, 2019·Cancer immunotherapy has revolutionized the treatment of cancer. Compared to chemotherapy and other drugs that directly kill tumor cells, cancer immunotherapy can stimulate and/or promote the immune system in the body to indirectly attack and kill tumor cells, with the goal of improving anti-tumor immunity while reducing off-target effects [1,2,3].

Kam W. Leong | Biomedical Engineering

He uses polymeric biomaterials to deliver chemotherapeutics, DNA-based therapeutics, and cells for cancer therapy, gene therapy, immunotherapy, and cell therapy. He also uses tissue engineering principles and stem cell engineering to construct human tissue-on-a-chip for disease modeling and high throughput drug screening.

Lymph Nodes-On-Chip: Promising Immune Platforms for ...

In vitro engineering of human Lymph node-on-a-Chip.(A) Schematic of the human native lymph node.(B) Requirements for in vitro biomimetic lymph node-on-chip. Requirements include: Biomimetic scaffold on which cells can be seeded or grown, cellular components (immune cells and stromal cells), appropriate extracellular matrix components, dynamic flow conditions, key features of the native lymph ...

Alex Najibi - PhD Candidate - Mooney Laboratory for Cell ...

I investigate biomaterials for immune modulation in cancer immunotherapy and tissue engineering, with particular emphasis on the role of lymph nodes in these responses. ... independent research ...

Polymeric scaffolds for antitumor immune cell priming ...

1.Introduction. Cancer is a life-threatening disorder, and is the second-leading cause of death worldwide, with an estimated 606,520 deaths projected in the USA alone for 2020 .Traditional treatments such as radiation, chemotherapy, and targeted cancer therapies have been associated with limited efficacy, leading to drug resistance, toxicity, and minimal survival benefit , , .

Department of Surgery - Lymphadenectomy

The substance or dye flows through the lymph ducts to the lymph nodes. The first lymph node to receive the substance or dye is removed. A pathologist views the tissue under a microscope to look for cancer cells. If cancer cells are found, more lymph nodes will be removed and tissue samples will be checked for signs of cancer.

Kam W. Leong | Columbia Engineering

He uses polymeric biomaterials to deliver chemotherapeutics, DNA-based therapeutics, and cells for cancer therapy, gene therapy, immunotherapy, and cell therapy. He also uses tissue engineering principles and stem cell engineering to construct human tissue-on-a-chip for disease modeling and …

3D bioprinting for reconstituting the cancer ...

Jul 27, 2020·Indeed, variations in expression of CD161(+) nonclassical T cells, CD4+ and CD8+ cells have been identified in lymph nodes, spleen, the mammary lymph nodes, and the tumor mass 91.

Biomaterials & Nanotechnology

1 天前·The development of immunoengineering technologies to direct immune cell function. We build artificial lymph nodes, mRNA vaccines and 3D printed interfaces to study and control immune cell behaviour. These technologies have applications in cancer therapy, inducing transplant tolerance, spaceflight and auto-immune diseases.

BioE PhD Defense Presentation- David Francis | BioE ...

Jun 05, 2020·Stem Cell Engineering ; Systems Biology ... "Enhancing immune checkpoint blockade and cancer immunotherapy via tissue targeting and biomaterial nanoparticles" ... one which proposes drugging tumor draining lymph nodes with ICB therapies by way of lymphatics using local rather than systemic administrations to enhance anti-tumor efficacy; and the ...